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KMID : 1094020140310030170
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Journal of Veterinary Clinics
2014 Volume.31 No. 3 p.170 ~ p.174
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Activation of Platelet Rich Plasma by Soluble Canine Small Intestinal Submucosa Gel and Bovine Thrombin
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Lee A-Jin
Lee Chang-Sun
Kim Hyun
Chung Dai-Jung
Kim Hwi-Yool
Do Sun-Hee
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Abstract
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This study evaluated the efficacy of soluble canine small intestinal submucosa gel in comparison to bovinethrombin in activating rabbit platelet rich plasma (PRP) by detecting growth factors. PRP from rabbits was activatedby using soluble canine SIS gel, bovine thrombin, or both. The surface morphology of each group of samples wasexamined by scanning electron microscopy. The release of transforming growth factor (TGF)-β1 from each set ofsamples was measured over 7 days using enzyme-linked immunosorbent assay. The PRP-canine SIS gel group exhibitedthe highest total amount of released TGF-β1. However, there were no significant differences between any groups. The use of soluble type of canine SIS gel could be an effective alternative to bovine thrombin.
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KEYWORD
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PRP (platelet-rich plasma) activation, soluble canine SIS (Small Intestinal Submucosa) gel, bovine thrombin, growth factor
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